The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy. Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem. Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ss-lactam antibiotics with ss-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.

The enormous genetic flexibility of bacteria jeopardizes the usefulness of currently available antibiotics, and requires new approaches to antibiotic discovery and development. Antimicrobial resistance can be acquired in a short time frame, both by genetic mutation and by direct transfer of resistance genes across genus and species boundaries. Understanding mechanisms of resistance is crucial to the future of antimicrobial therapy. Extensively revised, with contributions from international leaders in their fields, Bacterial Resistance to Antimicrobials, Second Edition blends scientific and practical approaches to the social, economic, and medical issues related to this growing problem. The book begins with a history of antimicrobial agents and bacterial resistance, and outlines the forces that contributed to the abuse of antibiotics and precipitated the current crisis. It goes on to describe what is known about the ecology of antibiotic resistant bacteria and reveals the inadequacies in our understanding. Emphasizing public health aspects, the editors stress that significant progress will be made only by addressing the problem only as a public, worldwide, problem. Chapters on resistance mechanisms describe the latest findings on what makes different groups of bacteria susceptible or resistant to antibiotics. They reveal the staggering diversity of bacteria and the need for a foundational understanding that will stimulate development of antibiotics capable of avoiding resistance mechanisms. Examining the success and limitations of complementary approaches, such as combining ss-lactam antibiotics with ss-lactamase inhibitors, the book brings together information on resistance mechanisms in different groups of bacteria to help future efforts to more effectively develop and deploy antimicrobial therapies.

A warmhearted story about the importance of having fun. When Floss leaves the town where she grew up to become a sheepdog on a farm, she'd like to play with the farmer's children. But with so much work, there's isn't time--until the farmer realizes his children need Floss as a companion as much as she need them. Full color.

Floss is a young border collie who belongs to an old man in a town and loves playing ball with the children in the park. The old man's son is a farmer and needs a new sheepdog to replace Nell, who has grown too old to work, so the old man decides to give his son Floss. Somewhere in her memory Floss knows about sheep and she soon learns how to be a sheepdog. But one day when Floss is on the hillside herding sheep, she sees the children playing with a new ball and can't resist joining in. Meanwhile the sheep escape - and the farmer is very angry. Floss is put in the doghouse, while Nell rounds up the sheep. But after this Floss becomes a very good sheepdog - although, when she has time, she still likes to play ball with the children. Kim Lewis has written three other books set on a Northumberland sheep farm, "Emma's Lamb", "First Snow" and "The Shepherd Boy" which was shortlisted for the 1991 Kate Greenaway Medal.

This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.

Education for adults ought to consider a both-and mindset when it comes to selecting approaches, values, and program models in today's multi-sector, multi-diverse, and cross-cultural environments of teaching and learning. Experiences from educational professionals can lead to recommendations for these instruction and mentoring approaches of adults that leads to more meaningful learning. Competency-Based and Social-Situational Approaches for Facilitating Learning in Higher Education is a critical research resource that discusses project-based and social-situational instructional practices within community engagement as a method for educating adults. The approaches to designing and implementing learning activities show how to optimize community and business knowledge assets to collaboratively design and implement curricula in order to work toward social justice and community development. Featuring coverage on a spectrum of topics such as community-based learning, political engagement, and urban communities, this book is ideal for professionals, adult education practitioners, faculty, administrators, community activists, researchers, and academicians.

This volume is a collection of chapters from the leading experts in the relatively new and burgeoning field of persister cell studies. Persisters play a leading role in the recalcitrance of chronic infections, and enable the development of classical antibiotic resistance. The focus of the book is on studies that provide an understanding of the mechanisms of persister formation, antibiotic tolerance and role in disease, at the molecular level.

Education for adults ought to consider a both-and mindset when it comes to selecting approaches, values, and program models in today's multi-sector, multi-diverse, and cross-cultural environments of teaching and learning. Experiences from educational professionals can lead to recommendations for these instruction and mentoring approaches of adults that leads to more meaningful learning. Competency-Based and Social-Situational Approaches for Facilitating Learning in Higher Education is a critical research resource that discusses project-based and social-situational instructional practices within community engagement as a method for educating adults. The approaches to designing and implementing learning activities show how to optimize community and business knowledge assets to collaboratively design and implement curricula in order to work toward social justice and community development. Featuring coverage on a spectrum of topics such as community-based learning, political engagement, and urban communities, this book is ideal for professionals, adult education practitioners, faculty, administrators, community activists, researchers, and academicians.

Drug resistance is increasing among a variety of human pathogenic microorganisms such as Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumaniii, Pseudomonas aeruginosa and Enterobacter spp. (currently dubbed the 'ESKAPE' pathogens), and has emerged as one of the most important clinical challenges of this century. Increased general awareness and fear of these pathogens means there is a growing demand for research to tackle the threat of multidrug resistance. Documenting the latest research in the field, this book discusses current and promising activities to discover new antimicrobials in five key areas: molecular genetics and systems microbiology; synthetic, computational chemistry and chemoinformatics; High Throughput Screening (HTS); non-vertebrate model hosts; and light- and nano-based technologies.

Kids will flock like sheep to Floss the border collie Acclaimed author-illustrator Kim Lewis has created another warm and evocative story that depicts the world of rural children and animals in affectionate detail. Floss has just had puppies, and the children want to know if they can keep one. "Maybe," their father says. "We could use another collie just like Floss to work with the sheep on the farm." But which one? Day after day the children watch the puppies grow, until one day Sam, the littlest, strays into the field. The sheep crowd around him, but instead of flinching, the puppy crouches low and runs, scattering the flock. "Big brave Sam," exclaim the children, racing after him, "just like Floss."